Cancer & Autoimmune Disease

Cancer and Autoimmune Disease increase risks and outcome of treatments

Autoimmune disease and cancer both attempt to control immune system, managing immune cells in different order. For patients diagnosed with both diseases it is hard to decide which therapy and how to use especially in cases when immunotherapy drugs called checkpoint inhibitors are involved. Patients with autoimmune disease have difficulty to tolerate such treatment when immune cells stimulated in order to recognize and attack cancer cells.

. Cancer and autoimmune diseases increase risks and treatments outcome and patients experience difficulty to stay in treatment protocol.

Autoimmune disorders cause inflammation which can lead to cancer. For example colitis or inflammatory bowel disease can rise chance of colorectal cancer. Chronic inflammation harm cell’s DNA and may result in unlimited cell growth. In order to reduce inflammation immunosuppressors are frequently adviced and both assumed on increasing multiple cancers risk .

Arthritis and psoriasis associated with increased lymphoma risk due to their pathophysiology, treatments or combination of these factors (Gelfand, 2006). Autoimmune diseases treatment is complicated by risk of activating pathological process which possible to avoid with modern immunomodulatory therapy.

With IPMs appearance there is hope for positive treatment outcome. Long-term therapy effect with IMP as STF in 70% rheumatoid arthritis cases reported excellent, very good and good results. Among those 34.3% responded good, 37.1% showed very good outcome and continued treatment with nonsteroid products and IMP in form of transfer factor. 28.6% with stage 1 rheumathoid arthritis achieved excellent results and withdrawn nonsteroid therapy.

Hence, transfer factor adjuvant therapy may be considered benefitial for patients with rheumatoid arthritis (Georgescu , 1985, 23(2):).


1. Addison’s disease 73. Ligneous conjunctivitis
2. Agammaglobulinemic 74. Linear IgA disease (LAD)
3. Alopecia areata 75. Lupus
4. Amyloidosis 76. Lyme disease chronic
5. Ankylosing spondylitis 77. Meniere’s disease
6. Anti-GBM/Anti-TBM nephritis 78. Microscopic polyangiitis (MPA)
7. Antiphospholipid syndrome 79. Mixed connective tissue disease (MCTD)
8. Autoimmune angioedema 80. Mooren’s ulcer
9. Autoimmune dysautonomia 81. Mucha-Habermann disease
10. Autoimmune encephalomyelitis 82. Multiple sclerosis
11. Autoimmune hepatitis 83. Myasthenia gravis
12. Autoimmune inner ear disease (AIED) 84. Myositis
13. Autoimmune myocarditis 85. Narcolepsy
14. Autoimmune pancreatitis 86. Neuromyelitis optica
15. Autoimmune retinopathy 87. Neutropenia
16. Autoimmune urticaria 88. Ocular cicatricial pemphigoid
17. Axonal & neuronal neuropathy (AMAN) 89. Optic neuritis
18. Baló disease 90. Palindromic rheumatism (PR)
19. Behcet’s disease 91. PANDAS
20. Benign mucosal pemphigoid 92. Paraneoplastic cerebellar degeneration (PCD)
21. Bullous pemphigoid 93. Paroxysmal nocturnal hemoglobinuria (PNH)
22. Castleman disease (CD) 94. Parry Romberg syndrome
23. Celiac disease 95. Pars planitis (peripheral uveitis)
24. Chagas disease 96. Parsonnage-Turner syndrome,
25. Chronic inflammatory demyelinating polyneuropathy (CIDP) 97. Pemphigus
26. Chronic recurrent multifocal osteomyelitis (CRMO) 98. Peripheral neuropathy
27. Churg-Strauss 99. Perivenous encephalomyelitis
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