Transfer factors include both inducer/helper functions (Inducer fractions) and regulatory functions (Regulator fractions)—historically called “suppressor fractions “.
The Inducer fractions transport an apparently mature immune response from the donor to the recipient.
Regulator fractions help control overreactions and limit allergies and autoimmune conditions.
The inducer fractions strengthen the antigenic stimulus, which induces the production of interferon gamma (IFN-γ), interleukin 2 (IL-2) and tumor necrosis factor alpha (TNF-α) by CD4+Th1 cells (A. Arnaudov, 2015).
As a result, cell-mediated immune response develops against the target antigen (Arnaudov, 2017) , and it comprises interleukins (IL-6 and IL-8) produced by activated monocytes.
Maturation of naive T cells as well as increased cell mediated immunity are regulated by the thymus. It is concured that transfer factor is more effectual in educating naive cells about the approaching danger. In the treatment of mild thymus primary immunodeficiency, both thymus and transfer factors are suggested
Several factors that decrease cell mediated immunity, Th2 supremacy are age, immunodeficiency, cytotoxic cancer treatments, chronical stress, metastatic diseases, environment, etc.
Suppressor fractions control and regulate the immune response to an antigen and stimulating the formation of IL-10 and inhibitory cytokines by Th2 cells (Krishnaveni, 2013) (Lawrence HS, 1996) (Burger DR, p. 1976).
The adjuvant-like components of Transfer Factor have a non-specific activity expressed by enhancing the immune response to other antigens or allergens (A.Gottlieb, 1980).